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PLoS ONE 7 , e51017 (2012)
for instance, iron accumulation in microglia and astrocytes promotes the release of proinflammatory cytokines, exacerbating neuroinflammation and neuronal damage (Ryan et al., 2023
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This type of inflammation is triggered in the dura mater by activation of the trigeminovascular system (TVS) through electrical or chemical stimuli, or the application of an inflammatory substance, rather than immune or microbial factors